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  大学ホームページ 図書館ホームページ 運営規程 登録・公開許諾書 パンフレット  更新日：2024/05/22    件数：7,050件     TOP  Language   JapaneseEnglishヘルプ No.1(全1件)     検索画面戻る一覧 Adverse drug events caused by drugs contraindicated for coadministration reported in the japanese adverse drug event report database and recognized by reportersこのページを印刷URL:   ダウンロード  IDJOS-bpb.b20-00986著者：名前根岸, 彰生/大島, 新司/堀井, 徳光/武藤, 香絵/井上, 直子/沼尻, 幸彦/大嶋, 繁/小林, 大介著者：別形式Negishi, Akio / Oshima, Shinji / Horii, Norimitsu / Mutoh, Mizue / Inoue, Naoko / Numajiri, Sachihiko / Ohshima, Shigeru / Kobayashi, Daisuke著者：カナネギシ, アキオ/オオシマ, シンジ/ホリイ, ノリミツ/ムトウ, ミズエ/イノウエ, ナオコ/ヌマジリ, サチヒコ/オオシマ, シゲル/コバヤシ, ダイスケ著者：所属城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科教育支援室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室著者：所属(別形式）Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Student Learning Assistance Center / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics著者版フラグpublisher出版地東京出版者日本薬学会出版者：カナニホンヤクガクカイ出版者：別名The Pharmaceutical Society of JapanNCIDAA10885497冊子ISSN09186158電子ISSN13475215掲載誌名Biological and Pharmaceutical Bulletin巻44号7刊行年月2021-07開始ページ932終了ページ936コンテンツ作成日2020-12-05コンテンツ修正日2021-04-25コンテンツ登録日2021-09-21識別番号：DOIinfo:doi/10.1248/bpb.b20-00986識別番号：DOI（リンク）https://doi.org/10.1248/bpb.b20-00986PubMed番号33967165NII論文ID130008060356抄録The “INTERACTIONS” section of package inserts aims to provide alert-type warnings in clinical practice; however, these also include many drug–drug interactions that occur rarely. Moreover, considering that drug–drug interaction alert systems were created based on package inserts, repeated alerts can lead to alert fatigue. Although investigations have been conducted to determine prescriptions that induce drug–drug interactions, no studies have focused explicitly on the adverse events induced by drug–drug interactions. We, therefore, sought to investigate the true occurrence of adverse events caused by drug pair contraindications for coadministration in routine clinical practice. Toward this, we created a list of drug combinations that were designated as “contraindications for coadministration” and extracted the cases of adverse drug events from the Japanese Adverse Drug Event Report database that occurred due to combined drug usage. We then calculated the reporters’ recognition rate of the drug–drug interactions. Out of the 2121 investigated drug pairs, drug–drug interactions were reported in 43 pairs, 23 of which included an injected drug and many included catecholamines. Warfarin potassium and miconazole (19 reports), azathioprine and febuxostat (11 reports), and warfarin potassium and iguratimod (six reports) were among the 20 most-commonly reported oral medication pairs that were contraindicated for coadministration, for which recognition rates of drug–drug interactions were high. Although these results indicate that only a few drug pair contraindications for coadministration were associated with adverse drug events (43 pairs out of 2121 pairs), it remains necessary to translate these findings into clinical practice.キーワードadverse drug event/drug–drug interaction/contraindicated combination/interaction recognition/alert fatigue/spontaneous reporting system注記V709210006

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