ヴェルダー

Researchers Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 　 Personnel Information 　 Profile 　 Degree 　 Research Interests 　 Research Areas 　 From School 　 From Graduate School 　 Employment Record in Research 　 External Career 　 Professional Memberships 　 Research Activity 　 Papers 　 Misc 　 Presentations 　 Awards 　 Scientific Research Funds Acquisition Results Updated on 2024/02/06 KAMAUCHI Hitoshi Affiliation Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Title Assistant Professor External Link To the head of this page.▲ Degree 【 display / non-display 】 To the head of this page.▲ Degree 【 display / non-display 】 博士 (薬科学) ( 2018.03   明治薬科大学 ) To the head of this page.▲ Research Interests 【 display / non-display 】 To the head of this page.▲ Research Interests 【 display / non-display 】 Natural product science To the head of this page.▲ Research Areas 【 display / non-display 】 To the head of this page.▲ Research Areas 【 display / non-display 】 Life Science / Environmental and natural pharmaceutical resources Life Science / Pharmaceutical chemistry and drug development sciences To the head of this page.▲ From School 【 display / non-display 】 To the head of this page.▲ From School 【 display / non-display 】 Meiji Pharmaceutical University   Faculty of Pharmaceutical Science   Graduated 2006.04 - 2010.03 　 More details Country：Japan To the head of this page.▲ From Graduate School 【 display / non-display 】 To the head of this page.▲ From Graduate School 【 display / non-display 】 Meiji Pharmaceutical University   Graduate School, Division of Pharmaceutical Sciences   Doctor&＃39;s Course   Completed 2015.04 - 2018.03 　 More details Country：Japan Meiji Pharmaceutical University   Graduate School, Division of Pharmaceutical Sciences   Master&＃39;s Course   Completed 2013.04 - 2015.03 　 More details Country：Japan To the head of this page.▲ Employment Record in Research 【 display / non-display 】 To the head of this page.▲ Employment Record in Research 【 display / non-display 】 Josai University   Faculty of Pharmaceutical Sciences   Department of Pharmaceutical Technochemistry   Assistant Professor 2022.04 Josai University   Faculty of Pharmaceutical Sciences   Department of Pharmaceutical Technochemistry   Research Assistant 2018.04 - 2022.03 To the head of this page.▲ External Career 【 display / non-display 】 To the head of this page.▲ External Career 【 display / non-display 】 Meiji Pharmaceutical University   Researcher 2011.04 - 2013.03 　 More details Country：Japan To the head of this page.▲ Professional Memberships 【 display / non-display 】 To the head of this page.▲ Professional Memberships 【 display / non-display 】 有機合成化学協会 2018.11 日本薬学会 2013.04 日本生薬学会 2013.04 To the head of this page.▲   Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 Synthesis and Biological Evaluation of 2-Azolylmethylene-3-(2H)-benzofuranone Derivatives as Potent Monoamine Oxidases Inhibitors Reviewed Koichi Takao, Yuka Kubota, Kota Kurosaki, Hitoshi Kamauchi, Yoshihiro Uesawa, Yoshiaki Sugita Chemical and Pharmaceutical Bulletin   72 ( 1 )   109 - 120   2024.01 　More details Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan   DOI： 10.1248/cpb.c23-00763 researchmap A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria Reviewed Hitoshi Kamauchi, Mayu Tanaka, Mitsuaki Suzuki, Miho Furukawa, Atsushi Ikeda, Chihiro Sasho, Yuka Kiba, Masashi Kitamura, Koichi Takao, Yoshiaki Sugita Chemical and Pharmaceutical Bulletin   72 ( 1 )   98 - 101   2024.01 　More details Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan   DOI： 10.1248/cpb.c23-00723 researchmap Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities Reviewed Hitoshi Kamauchi, Akifumi Takanashi, Mitsuaki Suzuki, Kouki Izumi, Koichi Takao, Yoshiaki Sugita Chemical and Pharmaceutical Bulletin   72 ( 1 )   56 - 60   2024.01 　More details Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan   DOI： 10.1248/cpb.c23-00693 researchmap Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains. International journal Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Hitoshi Kamauchi, Taishi Seki, Ryuichiro Suzuki, Masashi Kitamura Biomedicine & pharmacotherapy   169   115940 - 115940   2023.11 　More details Language：English   Publishing type：Research paper (scientific journal)   Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread as a pandemic and caused damage to people&＃39;s lives and countries&＃39; economies. The spike (S) protein of SARS-CoV-2 contains a cleavage motif, Arg-X-X-Arg, for furin and furin-like enzymes at the boundary of the S1/S2 subunits. Given that cleavage plays a crucial role in S protein activation and viral entry, the cleavage motif was selected as the target. Our previous fluorogenic substrate study showed that osthole, a coumarin compound, inhibits furin-like enzyme activity. In this study, we examined the potential activities of 15 compounds with a structure-activity relationship with osthole, and evaluated their protective ability against SARS-CoV-2 infection. Of the 15 compounds tested, compounds C1 and C2 exhibited the inhibitory effects of osthole against furin-like enzymatic activity; however, little or no inhibitory effects against furin activity were observed. We further examined the inhibition of SARS-CoV-2 activity by compounds C1 and C2 using a Vero E6 cell line that expresses the transmembrane protease serine 2 (TMPRSS2). Compounds C1, C2, and osthole effectively inhibited SARS-CoV-2 infection. Therefore, osthole and its derivatives can potentially be used as therapeutic agents against SARS-CoV-2. DOI： 10.1016/j.biopha.2023.115940 PubMed researchmap Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives Reviewed Hitoshi Kamauchi, Momoka Hirata, Koichi Takao, Yoshiaki Sugita ACS Omega   7 ( 45 )   41804 - 41814   2022.11 　More details Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)   DOI： 10.1021/acsomega.2c06260 researchmap display all >> To the head of this page.▲ Misc 【 display / non-display 】 To the head of this page.▲ Misc 【 display / non-display 】 Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed Journal of Synthetic Organic Chemistry, Japan   77 ( 9 )   895 - 903   2019.09 　More details Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   researchmap Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed Journal of Synthetic Organic Chemistry, Japan   77 ( 9 )   895 - 903   2019.09 　More details Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed 鎌内　等 ファルマシア   49 ( 4 )   333   2013.04 　More details Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：公益社団法人日本薬学会   エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed 鎌内 等 ファルマシア   49 ( 4 )   333 - 333   2013.04 　More details Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：公益社団法人日本薬学会   DOI： 10.14894/faruawpsj.49.4_333 CiNii Articles CiNii Books researchmap To the head of this page.▲ Presentations 【 display / non-display 】 To the head of this page.▲ Presentations 【 display / non-display 】 クロサイワイタケ科キノコ由来イソインドリノン化合物の合成 鎌内 等, 杉田 義昭 第65回天然有機化合物討論会  2023.09  　More details Event date： 2023.09 researchmap 菌糸-バイオフィルム形成阻害をターゲットとした真菌由来天然物の誘導体合成 鎌内 等, 木村 由, 牛渡 美琴, 關 大志, 鈴木 光明, 平田 桃香, 高尾 浩一, 杉田 義昭 第63回天然有機化合物討論会  2021.09  　More details Event date： 2021.09 researchmap 芳香族-テルペノイド天然物の誘導体合成と神経保護作用の評価 鎌内 等, 小田 拓未, 堀内 加奈世, 高尾 浩一, 杉田 義昭 第61回天然有機化合物討論会  2019.09  　More details Event date： 2019.09 researchmap To the head of this page.▲ Awards 【 display / non-display 】 To the head of this page.▲ Awards 【 display / non-display 】 長井記念若手薬学研究者賞 2023.03   日本薬学会   鎌内 等 　More details Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan 長井記念若手薬学研究者賞 2023.03   日本薬学会   鎌内 等 　More details Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan researchmap 平成28年度長井記念薬学研究奨励支援 2016   日本薬学会   鎌内　等 　More details Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan 平成28年度長井記念薬学研究奨励支援 2016   日本薬学会   鎌内 等 　More details Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan researchmap To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発 Grant number：20K16029  2020.04 - 2023.03 科学研究費助成事業  若手研究 鎌内等 　 More details Authorship：Principal investigator  Grant type：Competitive researchmap 天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発 2020.01 - 2023.03 科学研究費補助金  若手研究 鎌内等 To the head of this page.▲   Copyright © Josai University, All Rights Reserved.