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--> コンテンツへスキップ toggle navigation メインナビゲーション ホーム センター紹介 ごあいさつ センター概要 組織 メンバー 学生・胚培養士の方へ リカレント教育 社会人博士前後期課程 梨大胚培養士アカデミー 胚培養士養成 研究内容 研究成果 アクセス 研究成果 只今、準備中 Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis. Naitou Y, Nagamatsu G, Hamazaki N, Shirane K, Hayashi M, Hayashi M, Kobayashi S, Hayashi K. Development. 2022 Feb 15;149(4):dev2003191. Generation of ovarian follicles from mouse pluripotent stem cells. Yoshino T, Suzuki T, Nagamatsu G, Yabukami H, Ikegaya M, Kishima M, Kita H, Imamura T, Nakashima K, Nishinakamura R, Hayashi K. Science. 2021 Vol. 373, Issue 6552, eabe0237 Regulation of primordial follicle formation, dormancy, and activation in mice. Nagamatsu G*. J Reprod Dev. 2021 Jun 21;67(3):189-195. *Corresponding author. D-Tryptophan enhances the reproductive organ-specific expression of the amino acid transporter homolog Dr-SLC38A9 involved in the sexual induction of planarian Dugesia ryukyuensis. Maezawa T, Ishikawa M, Sekii K, Nagamatsu G, Furukawa R, Kobayashi K. Zoological Lett. 2021 Mar 20;7(1):4. Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice. Hamada N, Hamazaki N, Shimamoto S, Hikabe O, Nagamatsu G, Takada Y, Kato K, Hayashi K. PLoS Genet. 2020 Mar 26;16(3):e1008676. Environmental factors for establishment of the dormant state in oocytes. Hayashi K, Shimamoto S, Nagamatsu G. Dev Growth Differ. 2020 Apr;62(3):150-157. Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes. Nagamatsu G*, Shimamoto S, Hamazaki N, Nishimura Y, Hayashi K*. Sci Adv. 2019 Jun 26;5(6):eaav9960. *Corresponding author. Hypoxia induces the dormant state in oocytes through expression of Foxo3. Shimamoto S, Nishimura Y, Nagamatsu G, Hamada N, Kita H, Hikabe O, Hamazaki N, Hayashi K. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12321-12326. Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice. Nakajima K, Ono M, Radović U, Dizdarević S, Tomizawa SI, Kuroha K, Nagamatsu G, Hoshi I, Matsunaga R, Shirakawa T, Kurosawa T, Miyazaki Y, Seki M, Suzuki Y, Koseki H, Nakamura M, Suda T, Ohbo K. Dis Model Mech. 2019 Nov 12;12(11) Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells. Terada M, Kawamata M, Kimura R, Sekiya S, Nagamatsu G, Hayashi K, Horisawa K, Suzuki A. Genesis. 2019 Nov;57(11-12):e23334. Stem cells, in vitro gametogenesis and male fertility. Nagamatsu G, Hayashi K. Reproduction. 2017 Dec;154(6):F79-F91. Reconstitution in vitro of the entire cycle of the mouse female germ line. Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K. Nature. 2016 Nov 10;539(7628):299-303. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y. Stem Cell Reports. 2016 Dec 13;7(6):1072-1086. p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K. Cell Stem Cell. 2016 Aug 4;19(2):192-204. Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling. Nagamatsu G*, Saito S, Takubo K, Suda T. Stem Cell Reports. 2015 Jul 14;5(1):111-24. *Corresponding author. Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. Kinoshita T#, Nagamatsu G*#, Saito S, Takubo K, Horimoto K, Suda T. J Biol Chem. 2014 May 30;289(22):15776-87. *Corresponding author. #Equally contribution Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming. Kosaka T#, Nagamatsu G*#, Saito S#, Oya M, Suda T*, Horimoto K*. Cancer Sci. 2013 Aug;104(8):1017-26. *Corresponding author. #Equally contribution Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T. Cell Stem Cell. 2013 Jan 3;12(1):49-61. Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells. Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T. Biochem Biophys Res Commun. 2013 Nov 8;441(1):196-201. Conversion of primordial germ cells to pluripotent stem cells: methods for cell tracking and culture conditions. Nagamatsu G*, Suda T. Methods Mol Biol. 2013;1052:49-56. *Corresponding author. Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells. Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y. Biol Reprod. 2013 Feb 14;88(2):36. Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors. Nagamatsu G*, Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T. Stem Cells. 2013 Mar;31(3):479-87. *Corresponding author. Optimal ratio of transcription factors for somatic cell reprogramming. Nagamatsu G*, Saito S, Kosaka T, Takubo K, Kinoshita T, Oya M, Horimoto K, Suda T. J Biol Chem. 2012 Oct 19;287(43):36273-82. *Corresponding author. Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice. Nagamatsu G*, Kosaka T, Saito S, Takubo K, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T. Biol Reprod. 2012 Jun 14;86(6):182. *Corresponding author. A germ cell-specific gene, Prmt5, works in somatic cell reprogramming. Nagamatsu G*, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T*. J Biol Chem. 2011 Mar 25;286(12):10641-8. *Corresponding author. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Kinoshita T#, Nagamatsu G*#, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T. Biochem Biophys Res Commun. 2011 Apr 8;407(2):321-6. *Corresponding author. #Equally contribution Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A. Stem Cells. 2008 Dec;26(12):3237-46. Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T. Cell Stem Cell. 2008 Feb 7;2(2):170-82. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis. Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T. Biochem Biophys Res Commun. 2006 Dec 29;351(4):993-8. A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages. Nagamatsu G, Ohmura M, Mizukami T, Hamaguchi I, Hirabayashi S, Yoshida S, Hata Y, Suda T, Ohbo K. Mol Cell Biol. 2006 Nov;26(22):8498-506. The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Yoshida S, Sukeno M, Nakagawa T, Ohbo K, Nagamatsu G, Suda T, Nabeshima Y. Development. 2006 Apr;133(8):1495-505. Spatial analysis of germ stem cell development in Oct-4/EGFP transgenic mice. Ohmura M, Yoshida S, Ide Y, Nagamatsu G, Suda T, Ohbo K. Arch Histol Cytol. 2004 Nov;67(4):285-96. Regulation of expression of mouse interferon-induced transmembrane protein like gene-3, Ifitm3 (mil-1, fragilis), in germ cells. Tanaka SS, Nagamatsu G, Tokitake Y, Kasa M, Tam PP, Matsui Y. Dev Dyn. 2004 Aug;230(4):651-9. Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. Ogawa S, Nagamatsu G, Watanabe M, Watanabe S, Hayashi T, Horita S, Nitta K, Nihei H, Tezuka K, Abe R. J Immunol. 2001 Nov 15;167(10):5741-8. --> 〒400-8510甲府市武田4-4-37甲府東キャンパス　B1号館3階 TEL : 055-252-1111（代表）TEL : 055-220-8542Mail：ca&＃114;&＃116;&＃45;&＃97;&＃115;&＃64;&＃121;&＃97;&＃109;a&＃110;&＃97;&＃115;&＃104;&＃105;&＃46;&＃97;c&＃46;&＃106;&＃112; 最寄り駅から徒歩 JR甲府駅北口より武田通りを北上所要時間約15分 バス JR甲府駅北口バスターミナル2番乗り場「武田神社」または「積翠寺」行きバス停「山梨大学」下車所要時間約5分 車 中央自動車道「甲府昭和IC」で下りて、一般道を北東の方角へ国道20号線またはアルプス通り経由で約20分 国立大学法人 山梨大学 大学院 総合研究部 高度生殖補助技術センター