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--> MENU HOME About the museum The life and career of Professor Satoshi &＃332;mura Exhibition (collection) Museum Information・Access Japanese site UNIVERSITY OF YAMANASHI SATOSHI ŌMURA MUSEUM Access Japanese site UNIVERSITY OF YAMANASHI Commemorating the Opening of the Satoshi Ōmura Museum Equipment outline Professor Satoshi &＃332;mura Exhibition Corner Special exhibit Corner Kitenkan exhibit Corner Quartz exhibition corner The Quartz Collection House SATOSHI ŌMURA MUSEUM > The life and career of Professor Satoshi Ōmura The life and career of Professor Satoshi Ōmura Satoshi Ōmura and the University of Yamanashi Prof Satoshi Ōmura , a graduate of the University of Yamanashi, was awarded the Nobel Prize in Physiology or Medicine in 2015. His discovery of a novel soil-living actinomycete and the useful chemicals it produced has had – and continues to have &＃8211; an immeasurably beneficial impact in improving the health and livelihoods of hundreds of millions of people living in many of the world’s poorest communities throughout tropical regions. In addition many people in Japan and other wealthy countries in the world are also benefitting from the medicaments arising from that single microrganism, as well as the many other beneficial chemicals that Prof Ōmura has discovered. Prof Ōmura was born in 1935 in Kamiyama Village, Kita-Koma County, Yamanashi Prefecture (now part of Nirasaki City), entered the Faculty of Arts and Sciences of the University of Yamanashi (now the Faculty of Education) in 1954, and graduated in 1958. In further recognition of the excellent and unprecedented achievements of Prof Ōmura, the University of Yamanashi also awarded him a special Honorary Doctorate degree in October of 2015. Nobel Prize winning discovery In 1974, Prof Ōmura isolated an unknown strain of an actinomycete microorganism from a soil sample collected in Kawana, Ito City, Shizuoka Prefecture. In a joint study with Merck & Co., Inc. of the United States, it was found that the new strain, which Prof Ōmura had recognised as having unique properties not seen before in other actinomycetes, produced a novel chemical. This substance was discovered to be able to kill parasitic nematodes in mice. In 1979, the new strain was described in a scientific publication as a new species of actinomycete, Streptomyces avermitilis, and the antiparasitic substance was named avermectin. Subsequently, work was carried out to develop and examine a variety of derivatives of avermectin and a safer, more effective compound was produced, a dihydro-derivative named ivermectin. First marketed in 1981 on the animal health market, ivermectin soon became the world’s best selling product for use in killing parasites in livestock and pets. Researchers also began to explore its possible use in humans and it was found to be an ideal drug for treating one of the world’s most neglected tropical diseases that had plagued Africa for centuries. An ivermectin product, named Mectizan®, was manufactured for use in humans to treat Onchocerciasis (or River Blindness) throughout tropical regions in Africa, Latin America and the Middle East. In an unprecedented move, Merck & Co and the Kitasato Institute agreed to forego the income from sales of the drug for human use, resulting in 1987 in the start of the world’s most successful and longest running drug donation programme, one which persuaded many other major pharmaceutical companies to follow suit. Mectizan® was so safe and effective, it allowed public health authorities to switch from simply controlling River Blindness to the possibility of eliminating it. Ivermectin was such a unique drug that it was later seen to also be highly effective in combatting a similar devastating and disfiguring tropical disease, Lymphatic Filariasis (also known as Elephantiasis). Accordingly, the donation programme was extended in the late-1990s to provide ivermectin free of charge to help eliminate Lymphatic filariasis globally. In massive drug donation initiatives, Merck & Co, Inc, the Kitasato Institute and the World Health Organization and partners have been ensuring that around 300 million people have been taking donated Mectizan® tablets every year for 20-30 years. Hundreds of millions of the world’s poorest individuals, and their families, have had their health and welfare improved as a result. And both disease elimination programmes are approaching their goals. Ivermectin has also long been used to treat other disease in humans, such as strongyloidiasis, scabies, other skin diseases, and to kill head lice and new uses for this extraordinary drug are regularly being found. In Japan, ivermectin is sold under the brand name Stromectol® and is especially useful in preventing and treating skin complaints in the elderly. In addition to avermectin, Prof Ōmura has discovered over 500 new natural biologically active substances, mostly produced from microbes isolated from soil samples. Among these are staurosporine and lactacystin, which have contributed greatly to our understanding of life phenomena as research reagents and which, in particularly, have been forerunners in the development of highly-successful medicaments, notably anti-cancer agents. Scanning Electron Microscope Image of Streptomyces avermitilis NBRC14893T (MA-4680 strain) -As the tip of the hypha matures, it becomes a spiral and a spore chain is formed- Prof Satoshi Ōmura surrounded by schoolchildren in Ghana (2004)In Ghana (2004), where patients can receive free ivermectin to combat both onchocerciasis and lymphatic filariasis Biographical sketch 1935 Born as the eldest son of three children of the Ōmura family in Kamiyama Village, Kitakoma-gun, Yamanashi Prefecture (July 12). His father was a community leader and his mother was a school teacher (music/piano) 1939 A wooden Amida Nyorai of Ganjoji Temple and the statues on both sides of it (which Prof Ōmura’s father Yoshio and others ensured were saved from destruction) became a National Important Cultural Property 1942 Entered Kamiyama Village Kamiyama National School 1948 Graduated from Kamiyama Village Kamiyama Elementary School Entered Kamiyama Village Kamiyama Junior High School Integrated with Kamiyama Junior High School, the school became Nirasaki Junior High School, established by an association including Nirasaki City and Kamiyama Village.(July) 1951 Graduated from Nirasaki Junior High School Enrolled in Yamanashi Prefectural Nirasaki High School Joined Yamanashi Prefectural Nirasaki High School Table Tennis Club 1952 Joined Yamanashi Nirasaki High School Ski Club Joined Nirasaki Ski Club Encountered Yamadera Iwao, officer of the Yamanashi Prefectural Ski Association 1953 Becomes leader of Yamanashi Prefectural Nirasaki Senior High School Table Tennis club Wins 3rd place prize in the 7th Yamanashi ski championship long distance high school student division Father recommends going to university and becoming a surgeon. 1954 Graduated Yamanashi Prefectural Nirasaki High School Entered the Department of Natural Sciences, Faculty of Arts and Sciences, University of Yamanashi Studied under Senjiro Maruta, a Chemistry Professor, and served as a Research Assistant for Motonoshin Tanaka, a Professor of Earth Sciences. Studied under Ryusaku Yokoyama (who was called the &＃8220;Emperor of Skiing&＃8221;) Won the long-distance division of the 8th Yamanashi Prefecture ski championship 1955 Won the long-distance division of the 9th Yamanashi Prefecture ski championship 1956 Won both the long-distance division of the 10th Yamanashi Prefecture ski championship and as a member of Nirasaki Ski Club, the club competition relay Won the long-distance youth division, the youth slalom division and the youth grand slalom division of the 1st Amariyama Ski Championship 1957 Participated as the representative of Yamanashi Prefecture in the long-distance skiing division of the 11th National Athletic Meet Winter Games (Aomori Prefecture) Won both the long-distance division of the 11th Yamanashi Prefecture ski championship and as a member of Nirasaki Ski Club, the club competition relay Won the long-distance youth division and the youth slalom division of the 2nd Amariyama Ski Championship 1958 Participated as the representative of Yamanashi Prefecture in the long-distance skiing division of the 12th National Athletic Meet Winter Games (Hyogo Prefecture) Won the long-distance youth division, the youth slalom division and the youth grand slalom division of the 1st Amariyama Ski Championship Won the long-distance division of the 12th Yamanashi Prefecture ski championship Introduced to the University of Yamanashi’s Prof Adachi Sada by Prof Motonoshin Tanaka Graduated from the University of Yamanashi Faculty of Arts and Sciences, Department of Natural Science Became a night school teacher at Tokyo Metropolitan Sumida Technical High School Began to learn German under Bunpei Koro 1959 Introduced to Prof Tetsujiro Obara from Tokyo University of Education by Senjiro Maruta Learned about IR (infrared absorption) spectrum under Koji Nakanishi (who was later awarded the 2007 Japan’s Order of Culture) 1960 Enrolled in the Master&＃8217;s programme at the Graduate School of Science, Tokyo University of Science Studied under the guidance of Prof Yojiro Tsuzuki and Nobuo Mori 1961 Congratulatory address as student representative at the 80th anniversary ceremony of Tokyo University of Science. A congratulatory speech was also given by Fumiko Akiyama, who later became Prof Ōmura’s wife. 1962 Led Tokyo Metropolitan Sumida Technical High School Table Tennis Club to second place in the Tokyo Metropolitan Games 1963 Completed Master&＃8217;s degree at the Tokyo University of Science Mar. 23 married Fumiko Akiyama Retired from high school teaching and was assigned as an Assistant Professor to Motoo Kagami, a Professor of fermentation production at the Faculty of Engineering, University of Yamanashi, and became interested in microorganisms. 1964 After being told by Koji Yamakawa, Professor, Faculty of Pharmaceutical Sciences, Tokyo University of Science of an opportunity for research work at the Kitasato Institute, headed by Toju Hata, passes the recruitment test. 1965 Appointed to the Kitasato Institute as an Assistant Professor in the Antibiotics Research Laboratory Started research on the structure determination of leucomycins (completed in 1967) Started research on the isolation and structural study of cerulenin (completed in 1967) 1968 Received Ph.D. in Pharmaceutical Sciences, University of Tokyo (under the guidance of Prof Toshihiko Okamoto) 1969 Promoted to Associate Professor, Faculty of Pharmaceutical Sciences, Kitasato University Visited various universities and pharmaceutical companies located in Europe as a member of the Japanese Society for Pharmaceutical Research 1970 Received the Kitasato Institute Award to Encourage Academic Studies Awarded a Doctor of Science degree from the Tokyo University of Science (under the guidance of Prof Yojiro Tsuzuki, Faculty of Science) 1971 On the advice of Yukimasa Yagisawa, Executive Director, Japan Society for the Study of Antibiotics, travels to Canada and the US with a view to studying abroad (March) Invited as a Visiting Research Professor at Wesleyan University in the United States under the guidance of Professor of Chemistry Max Tishler (September) Met Konrad Bloch (a Biochemistry Professor at Harvard University, and winner of the Nobel Prize for Physiology or Medicine in 1964). Conducted a joint research project on cerulenin to clarify its mechanism of action, working in the Bloch Research Laboratory at Harvard. 1972 Interacted with prominent researchers, including Roy Vagelos, Professor of Medicine at the University of Washington, who would later become President of Merck &＃038; Co., Inc. 1973 Completed research work abroad and returned to Japan (January) Appointed as Director of the Antibiotics Office, Kitasato Institute and Assistant Professor, School of Pharmaceutical Sciences, Kitasato University Personally negotiated and signed a joint research memorandum between Kitasato Institute and Merck &＃038; Co., Inc. on the discovery and development of useful natural compounds including veterinary drugs, and began the joint research project in Japan (March) 1974 Discovered the novel “OS-3153” actinomycete microbe from soil collected in Kawana, Ito City, Shizuoka Prefecture. After establishing that it had a unique microbial activities and character, and produced interesting metabolic chemicals, sent the organism to Merck &＃038; Co., Inc for further testing as part of the joint research project 1975 Promoted to Professor, Kitasato University (April) Started Kitasato Microbial Chemistryeminar 1977 After notified the closure of the Kitasato Institute&＃8217;s Ōmura laboratory (for financial reasons), began operating under a financially independent system Discovery of protein kinase inhibitor staurosporine (November) 1979 Gave a presentation at an international conference and published in the Scientific Journal regarding the discovery of a potent anthelmintic compound “Avermectin” 1980 Developed Ivermectin (dihydro derivative of avermectin), improved the spectrum of activity and safety than avermectin 1981 Merck &＃038; Co., Inc begins sales of ivermectin as an antiparasitic drug for animals and avermectin as an agrochemical Appointed as Auditor of the Kitasato Institute Exchange with China begins through the invitation of the Chinese Academy of Sciences and the Beijing Antibacterial Research Institute 1982 Submitted proposal for the construction of a new Kitasato Institute hospital (August) 1983 Met British biologist Sydney Brenner (winner of the 2002 Nobel Prize in Physiology or Medicine) 1984 Appointed Trustee and Deputy Director of the Kitasato Institute 1985 Received the Hoechst-Russell Award from the American Society for Microbiology and internationally recognized for his research work and achievements 1986 Received the Pharmaceutical Society of Japan Award 1987 Ivermectin was developed as a treatment for Onchocerciasis in humans and donated for use in treating the disease Re-elected as Deputy Director of the Kitasato Institute 1989 Established the Max Tishler Memorial Symposium in honour of his mentor, Max Tishler Held the 1st Celebration of Humanity Award Exhibition (aiming to draw attention to the use of paintings in hospitals to help promote recovery as part of the global “Healing Art” movement) Opened the Kitasato Institute Medical Center Hospital (a “Healing Art” hospital) Received the Uehara Award (from the Uehara Memorial Life Science Foundation) 1990 Appointed Director of the Kitasato Institute Received the Japan Academy Award 1991 Special lecture at the 100th anniversary ceremony of Germany’s Robert Koch Institute Received the Charles Thom Award from the American Society for Industrial Microbiology Discovered the proteasome inhibitor lactacystin 1992 Received Japan’s Medal of Honor with Purple Ribbon Awarded France’s l’Ordre National du Merite (Chevalier) Selected as a Foreign Member of the German Academy of Sciences Leopoldina 1993 Gave a special invited lecture at Harvard University Developed friendship with Nobel Laureates Conrad Bloch and Elias Corey Moved the Kitasato Institute Research Center for Biologicals to the Kitamoto Business Site Appointed Director of Joshibi University of Art and Design 1994 Established a Nursing School at the Kitamoto site to nurture ‘nurses with a generous heart’ Selected as an Honorary Member of Germany’s Robert Koch Institute Received Honorary Doctor Degree of Science from Wesleyan University, attended ceremony with wife, Fumiko 1995 Received the American Society of Industrial Microbiology Achievement Award Received the Fujiwara Award (from the Fujiwara Science Foundation) Received a Special Achievement Award from the Society of Actinomycetes, Japan 1997 Appointed Chairman of Joshibi University of Art and Design Received the Robert Koch Foundation’s, Robert Koch Gold Medal, Germany’s highest medical award Received Thailand’s Prince Mahidol Award 1998 Selected as Honorary Member of the Chemical Society of Japan Ivermectin began to be donated free of charge for the eradication of lymphatic filariasis 1999 Opened Kitasato Nursing College&＃8217;s annex Wang Senran Memorial Hall, and invited Wang Senran and his wife to the ceremony Selected as a Foreign Member of the United States National Academy of Sciences 2000 Received the Nakanishi Prize (American Chemical Society, The Chemical Society of Japan) Established the &＃8220;100th Anniversary Foundation Ōmura Fumiko Fund&＃8221; at Joshibi University of Art and Design Fumiko Ōmura, passed away The Women&＃8217;s Painters Association established the &＃8220;Fumiko Ōmura Memorial Award&＃8221; Received the &＃8220;Noguchi Prize&＃8221; from Yamanashi Nichinichi Shimbun and the Yamanashi Broadcasting System. Inc. Become an Honorary Citizen of Nirasaki City 2001 Selected as a member of the Japan Academy Published a genetic analysis of the avermectin-producing actinomycete Streptomyces avermectinius (previously known as S. avermitilis), the first genetic map of a commercially important actinomycete Founded the &＃8220;Kitasato Institute for Life Sciences&＃8221; in the Kitasato University and appointed as the inaugural Director and as a teaching professor 2002 Appointed as a Founding Professor of the &＃8220;Kitasato University Graduate School of Infection Control Sciences&＃8221; Awarded the Yamanashi Prefectural Government Special Achievement Award Selected as a Foreign Member of the French Academy of Sciences 2003 Established the Yamanashi Academy of Sciences with supporters to accumulate intellectual property in Yamanashi Prefecture (May) Selected as a Special Honorary Member of the Japanese Society of Bacteriology 2004 Visited Ghana and Burkina Faso in west Africa, including the headquarters of the African Programme for Onchocerciasis Control (APOC), Ghana’s Noguchi Institute, and bush villages, such as Asubende ,which are famous as the worst disease-affected sites where the scientific fight against onchocerciasis began and where all villagers are now taking free ivermectin Received the Ernest Gunther Award from the American Chemical Society 2005 Selected as a Foreign Member of the Chinese Academy of Engineering Appointed as inaugural Max Tishler Professor of Chemistry at Wesleyan University Selected as Honorary Member of the Society for Actinomycetes Japan 2006 Appointed an Honorary Advisor to University of Yamanashi 2007 Appointed Professor Emeritus of Kitasato University Re-elected as Chairman of Joshibi University of Art and Design Received the International Chemotherapy Society’s Hamao Umezawa Memorial Award Opened the Nirasaki Ōmura Art Museum 2008 Appointed Honorary Chairman of the Kitasato Institute, which had merged with Kitasato Gakuen-Kitasato University Appointed as Special Coordinator of the Project for Multidisciplinary Cooperation in Screening for Biologically Active Compounds of Microbial Origin, Kitasato Institute for Life Sciences, Kitasato University Donated the Ōmura Art Museum buildings and collected works to Nirasaki City 2009 Appointed Chairman of Yamanashi Academy of Sciences 2010 Received the Tetrahedron Prize for Creativity in Organic Chemistry 2011 Awarded the Arima Prize of the International Union of Microbiology Received the Order of the Sacred Treasure, Gold and Silver Star (National Medal of Japan) 2012 Appointed an Advisor at the Kitasato Institute Honored as an Honorary Citizen of Nirasaki City, Yamanashi Prefecture Selected as a Japan’s Person of Cultural Merit 2013 Appointed as a Distinguished Emeritus Professor at Kitasato University Selected as an Honorary Member of the Pharmaceutical Society of Japan 2014 Received the Gairdner Global Health Award (from Canada’s Gairdner Foundation) Received a Special Award from the Mayor of Nirasaki City Gave the Nirasaki Municipal System 60th Anniversary Commemorative Lecture 2015 Received the Asahi Award Appointed Honorary Chairman of Yamanashi Academy of Sciences Appointed Honorary Chairman of Joshibi University of Art and Design Selected as Person of Special Cultural Merit by Yamanashi Prefecture Received Japan’s Order of Culture Received the Nobel Prize in Physiology or Medicine Received the Tokyo Honor Award Received the Medal of Honor for Setagaya Ward Received a Special Honorary Doctorate from the University of Yamanashi Honored as an Honorary Citizen of Yamanashi Prefecture 2016 Appointed Max Tishler Professor Emeritus of Chemistry at Wesleyan University Awarded the Saitama Prefecture Honorary Medal Received the Saitama Citizen of Honor Award Received a Special Honorary Doctorate degree from the Tokyo University of Science Received an Honorary Doctoral degree (Art) from Joshibi University of Art and Design Received an Honorary Doctorate from Shanghai Jiao Tong University Honored as an Honorary Citizen of Tokyo Honored as an Honorary Citizen of Kitamoto City, Saitama Prefecture 2017 Honored as an Honorary Resident of Setagaya-ku, Tokyo 2018 Received Honorary Degree of Doctor of Science from St. Andrews University, UK Research achievements (discovery and development of some major biologically active compounds, etc.) 1967 Discovery of cerulenin (fatty acid biosynthesis inhibitor) 1968 Isolation of 10 components of the antibacterial antibiotic leucomycin and determination of their structure 1974 Discovery of the antifungal nanaomycin 1977 Discovery of staurosporine (protein kinase inhibitor) Discovery of vineomycin (prolyl hydroxylase inhibitor) 1978 Discovery of the antibacterial frenolicin B Discovery of elasnin (elastase inhibitor) 1979 Discovery and development of the antiparasitic avermectin/Ivermectin Discovery of herbimycin (Hsp90 inhibitor) Discovery of neoxaline (cell cycle inhibitor) 1981 Discovery of setamycin (V-ATPase inhibitor) Development of the semi-synthetic antibacterial rokitamycin 1982 Developed the semi-synthetic antibacterial, tilmicosin Discovery of virustomycin (antiviral substance) 1984 Discovery of kazusamycin, an inhibitor of nuclear export and an anti-tumour compound 1985 Discovery of the semi-synthetic antibiotic motilide Creation of the first hybrid antibiotic mederrhodin by genetic engineering 1986 Discovery of triacsin (acyl CoA synthase inhibitor) 1987 Discovery of hymeglusin (HMG-CoA synthase inhibitor) 1988 Discovery of atpenin (Complex II inhibitor) 1991 Discovery of lactacystin (proteasome inhibitor) 1995 Discovery of macrosphelide (cell adhesion inhibitor) Discovery of amidepsine (DGAT inhibitor) 1996 Discovery of madindrin (IL-6 inhibitor) Discovery of andrastin (farnesyl transferase inhibitor) 1999 Discovery of beauveriolide (ACAT inhibitor) Discovery of funalenone (integrase inhibitor) 2001 Genome decoding and mapping of the avermectin-producing bacterium S. avermectinius Discovered nafuredin (nematode Complex I inhibitor) 2005 Creation and development of afidopyropen (agricultural pest control agent) 2008 Discovery of guadinomine (Type III secretory mechanism inhibitor) 2012 Discovery of wickerol (anti-influenza virus substance) Research collaborators Juichi Awaya, Haruo Ikeda, Junji Inokoshi, Nobutaka Imamura, Yuzuru Iwai, Masato Iwatsuki, Hideo Utsuno, Chiaki Kitao, Hiroie Ohno, Ruiko Oiwa, Kazuhiko Otoguro, Yongpil Kim, Kanki Komiyama, Kazuro Shiomi, Toshiaki Sunazuka, Yoko Takahashi, Satoshi Takamatsu, Haruo Tanaka, Kazuo Tsuzuki, Akira Nakagawa, Toru Nagamitsu, Kenichi Nonaka, Setsuzo Nomura, Masahiko Hayashi, Tomoyasu Hirose, Tomoko Fujimoto, Shinji Funayama, Rokurou Masuma, Keiichi Matsuzaki, Atsuko Matsumoto. back to top ▲ About the museum - Commemorating the Opening of the Satoshi Ōmura Museum - Equipment outline The life and career of Professor Satoshi &＃332;mura Exhibition (collection) - Professor Satoshi &＃332;mura Exhibition Corner - Special exhibit Corner - Kitenkan exhibit Corner - Quartz exhibition corner - The Quartz Collection House Museum Information・Access SATOSHI &＃332;MURA MUSEUM4-4-37, Takeda, Kofu-city, Yamanashi Prefecture, JAPAN 400-8510Tel : +81(0)55-220-8059　Fax : +81(0)55-220-8378 Copyright© 2018 SATOSHI &＃332;MURA MUSEUM. 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